Executive Order 14363

Launching the Genesis Mission

Signed 2025-11-24 in effect
AIEnergyScienceTechnology
Technology & Innovation

Launches the 'Genesis Mission,' a coordinated national effort led by the Secretary of Energy to use AI to accelerate scientific discovery across priority domains such as semiconductors, biotechnology, and quantum computing.

Section by Section

What each section does, and how they differ.

Sec. 1 Purpose. From the founding of our Republic,

Establishes the Genesis Mission as a historic national AI effort to advance scientific discovery across priority domains including semiconductors, biotechnology, and quantum computing.

Sec. 2 Establishment of the Genesis Mission

Creates the mission structure under DOE oversight with an Artificial Intelligence Science Planning Team to coordinate interagency research and development activities.

Sec. 3 Operation of the American Science and Security

Directs DOE to operate the American Science and Security Platform providing high-performance computing, AI models, datasets, and experimental tools for mission research.

Sec. 4 Identification of National Science and

Requires DOE to identify at least 20 national science and technology challenges within 60 days and coordinate an expanded list through the National Science and Technology Council.

Sec. 5 Interagency Coordination and External

Tasks the APST and NSTC with convening agencies to align AI programs, develop data integration processes, fund research competitions, and establish fellowships in AI-driven science.

Sec. 6 Evaluation and Reporting

Directs annual reporting to the President on progress toward mission objectives, implementation of research and development priorities, and recommendations for interagency coordination.

Sec. 7 General Provisions

Standard boilerplate: preserves existing agency authority, conditions the order on appropriations, and creates no enforceable private rights.