Executive Order 14355

Unlocking Cures for Pediatric Cancer with Artificial Intelligence

Signed 2025-09-30 in effect
HealthcareArtificial IntelligenceCancerChildren
Technology & InnovationHealth

Directs the use of AI technologies in federal cancer research programs to accelerate the development of treatments for pediatric cancers.

Section by Section

What each section does, and how they differ.

Sec. 1 Purpose and Policy. My Administration is

Establishes the MAHA Commission goal to accelerate AI innovation in pediatric cancer research and treatment in coordination with NIH and other agencies.

Sec. 2 Harnessing American AI Innovation. The MAHA

Directs the MAHA Commission and APST to coordinate with federal agencies and private sector to expand AI-driven pediatric cancer research and clinical applications.

Sec. 3 Increasing Investment and Engagement in

Tasks MAHA Commission and NIH to identify strategies for increasing federal investment in pediatric cancer initiatives and encouraging private AI innovation in treatments.

Sec. 4 Improving Data Sharing and Empowering Patients

Directs HHS to work with APST to integrate AI into health data interoperability efforts, maximize electronic health record and claims data for research, and finalize AI-focused data standards.

Sec. 5 Definition. For the purposes of this order,

Defines artificial intelligence for purposes of this order consistent with federal AI policy frameworks.

Sec. 6 General Provisions

Standard boilerplate: preserves existing agency authority, conditions the order on appropriations, and creates no enforceable private rights.